What's your prefered gamepad design? For most games, I like the asymmetrical design of the xbox or some of the nintendo controllers. The thumbs rest naturally on the left stick and face buttons, the inputs you are often using in 3d games.
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Extended thoughts, for 2d platformers or retro games. I prefer the symmetrical design of playstation controllers or the wii's pro controller. The placement of the d-pad and face buttons are perfectly where your thumbs are.
It depends on the game. Katamari requires symetrical sticks, practically unplayable without it.